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CCL5-armed oncolytic virus augments CCR5-engineered NK cell infiltration and antitumor efficiency

BACKGROUND: Natural killer (NK) cells have potent antitumor activities. Nevertheless, adoptive transfer therapy of NK cells has gained very limited success in patients with solid tumors as most infused NK cells remain circulating in the peripheral blood instead of entering tumor sites. Chemokines an...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Li, Feng, Sheng, Yuqiao, Hou, Weizhou, Sampath, Padma, Byrd, Daniel, Thorne, Stephen, Zhang, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7057442/
https://ncbi.nlm.nih.gov/pubmed/32098828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2019-000131
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