Chimeric antigen receptor T cells secreting anti-PD-L1 antibodies more effectively regress renal cell carcinoma in a humanized mouse model

Advances in the treatment of metastatic clear cell renal cell carcinoma (ccRCC) have led to improved progression-free survival of many patients; however the therapies are toxic, rarely achieve durable long-term complete responses and are not curative. Herein we used a single bicistronic lentiviral v...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Suarez, Eloah Rabello, Chang, De-Kuan, Sun, Jiusong, Sui, Jianhua, Freeman, Gordon J., Signoretti, Sabina, Zhu, Quan, Marasco, Wayne A.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085160/
https://ncbi.nlm.nih.gov/pubmed/27145284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9114
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