Role of a Novel Human Leukocyte Antigen-DQA1*01:02;DRB1*15:01 Mixed Isotype Heterodimer in the Pathogenesis of “Humanized” Multiple Sclerosis-like Disease

Gene-wide association and candidate gene studies indicate that the greatest effect on multiple sclerosis (MS) risk is driven by the HLA-DRB1*15:01 allele within the HLA-DR15 haplotype (HLA-DRB1*15:01-DQA1*01:02-DQB1*0602-DRB5*01:01). Nevertheless, linkage disequilibrium makes it difficult to define,...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Kaushansky, Nathali, Eisenstein, Miriam, Boura-Halfon, Sigalit, Hansen, Bjarke Endel, Nielsen, Claus Henrik, Milo, Ron, Zeilig, Gabriel, Lassmann, Hans, Altmann, Daniel M., Ben-Nun, Avraham
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463466/
https://ncbi.nlm.nih.gov/pubmed/25911099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.641209
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