DQB1*0602 rather than DRB1*1501 confers susceptibility to multiple sclerosis-like disease induced by proteolipid protein (PLP)

BACKGROUND: Multiple sclerosis (MS) is associated with pathogenic autoimmunity primarily focused on major CNS-myelin target antigens including myelin basic protein (MBP), proteolipidprotein (PLP), myelin oligodendrocyte protein (MOG). MS is a complex trait whereby the HLA genes, particularly class-I...

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Hauptverfasser: Kaushansky, Nathali, Altmann, Daniel M, David, Chella S, Lassmann, Hans, Ben-Nun, Avraham
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3344688/
https://ncbi.nlm.nih.gov/pubmed/22316121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-29
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