Streptozotocin Stimulates the Ion Channel TRPA1 Directly: INVOLVEMENT OF PEROXYNITRITE

Streptozotocin (STZ)-induced diabetes is the most commonly used animal model of diabetes. Here, we have demonstrated that intraplantar injections of low dose STZ evoked acute polymodal hypersensitivities in mice. These hypersensitivities were inhibited by a TRPA1 antagonist and were absent in TRPA1-...

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Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Andersson, David A., Filipović, Milos R., Gentry, Clive, Eberhardt, Mirjam, Vastani, Nisha, Leffler, Andreas, Reeh, Peter, Bevan, Stuart
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2015
Teme:
Neurobiology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463460/
https://ncbi.nlm.nih.gov/pubmed/25903127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.644476
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