Assembly of the Elongin A Ubiquitin Ligase Is Regulated by Genotoxic and Other Stresses

Elongin A performs dual functions in cells as a component of RNA polymerase II (Pol II) transcription elongation factor Elongin and as the substrate recognition subunit of a Cullin-RING E3 ubiquitin ligase that has been shown to target Pol II stalled at sites of DNA damage. Here we investigate the m...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Weems, Juston C., Slaughter, Brian D., Unruh, Jay R., Hall, Shawn M., McLaird, Merry B., Gilmore, Joshua M., Washburn, Michael P., Florens, Laurence, Yasukawa, Takashi, Aso, Teijiro, Conaway, Joan W., Conaway, Ronald C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Gene Regulation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463447/
https://ncbi.nlm.nih.gov/pubmed/25878247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.632794
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