Assembly of the Elongin A Ubiquitin Ligase Is Regulated by Genotoxic and Other Stresses

Elongin A performs dual functions in cells as a component of RNA polymerase II (Pol II) transcription elongation factor Elongin and as the substrate recognition subunit of a Cullin-RING E3 ubiquitin ligase that has been shown to target Pol II stalled at sites of DNA damage. Here we investigate the m...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Weems, Juston C., Slaughter, Brian D., Unruh, Jay R., Hall, Shawn M., McLaird, Merry B., Gilmore, Joshua M., Washburn, Michael P., Florens, Laurence, Yasukawa, Takashi, Aso, Teijiro, Conaway, Joan W., Conaway, Ronald C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2015
Matèries:
Gene Regulation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463447/
https://ncbi.nlm.nih.gov/pubmed/25878247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.632794
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