Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington’s disease patients

BACKGROUND: Quantification of disease-associated proteins in the cerebrospinal fluid (CSF) has been critical for the study and treatment of several neurodegenerative disorders; however, mutant huntingtin protein (mHTT), the cause of Huntington’s disease (HD), is at very low levels in CSF and, to our...

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Foilsithe in:J Clin Invest
Main Authors: Wild, Edward J., Boggio, Roberto, Langbehn, Douglas, Robertson, Nicola, Haider, Salman, Miller, James R.C., Zetterberg, Henrik, Leavitt, Blair R., Kuhn, Rainer, Tabrizi, Sarah J., Macdonald, Douglas, Weiss, Andreas
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2015
Ábhair:
Clinical Medicine
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463213/
https://ncbi.nlm.nih.gov/pubmed/25844897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI80743
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