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Calcium release channel RyR2 regulates insulin release and glucose homeostasis

The type 2 ryanodine receptor (RyR2) is a Ca(2+) release channel on the endoplasmic reticulum (ER) of several types of cells, including cardiomyocytes and pancreatic β cells. In cardiomyocytes, RyR2-dependent Ca(2+) release is critical for excitation-contraction coupling; however, a functional role...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Santulli, Gaetano, Pagano, Gennaro, Sardu, Celestino, Xie, Wenjun, Reiken, Steven, D’Ascia, Salvatore Luca, Cannone, Michele, Marziliano, Nicola, Trimarco, Bruno, Guise, Theresa A., Lacampagne, Alain, Marks, Andrew R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463204/
https://ncbi.nlm.nih.gov/pubmed/25844899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI79273
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