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Structural Insight into an Alzheimer’s Brain-Derived Spherical Assembly of Amyloid β by Solid-State NMR

[Image: see text] Accumulating evidence suggests that various neurodegenerative diseases, including Alzheimer’s disease (AD), are linked to cytotoxic diffusible aggregates of amyloid proteins, which are metastable intermediate species in protein misfolding. This study presents the first site-specifi...

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Bibliografiske detaljer
Udgivet i:J Am Chem Soc
Main Authors: Parthasarathy, Sudhakar, Inoue, Masafumi, Xiao, Yiling, Matsumura, Yoshitaka, Nabeshima, Yo-ichi, Hoshi, Minako, Ishii, Yoshitaka
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2015
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4462565/
https://ncbi.nlm.nih.gov/pubmed/25938164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b03373
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