Structural Insight into an Alzheimer’s Brain-Derived Spherical Assembly of Amyloid β by Solid-State NMR

[Image: see text] Accumulating evidence suggests that various neurodegenerative diseases, including Alzheimer’s disease (AD), are linked to cytotoxic diffusible aggregates of amyloid proteins, which are metastable intermediate species in protein misfolding. This study presents the first site-specifi...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Parthasarathy, Sudhakar, Inoue, Masafumi, Xiao, Yiling, Matsumura, Yoshitaka, Nabeshima, Yo-ichi, Hoshi, Minako, Ishii, Yoshitaka
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4462565/
https://ncbi.nlm.nih.gov/pubmed/25938164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b03373
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