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Molecular-Level Examination of Cu(2+) Binding Structure for Amyloid Fibrils of 40-Residue Alzheimer’s β by Solid-State NMR Spectroscopy

[Image: see text] Cu(2+) binding to Alzheimer’s β (Aβ) peptides in amyloid fibrils has attracted broad attention, as it was shown that Cu ion concentration elevates in Alzheimer’s senile plaque and such association of Aβ with Cu(2+) triggers the production of neurotoxic reactive oxygen species (ROS)...

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書誌詳細
主要な著者: Parthasarathy, Sudhakar, Long, Fei, Miller, Yifat, Xiao, Yiling, McElheny, Dan, Thurber, Kent, Ma, Buyong, Nussinov, Ruth, Ishii, Yoshitaka
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3074258/
https://ncbi.nlm.nih.gov/pubmed/21341665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja1072178
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