Aβ(1–42) Fibril Structure Illuminates Self-recognition and Replication of Amyloid in Alzheimer’s

Increasing evidence suggests that formation and propagation of misfolded aggregates of 42-residue human amyloid β (Aβ(1–42)), rather than the more abundant Aβ(1–40), provokes the Alzheimer’s cascade. To date, structural details of misfolded Aβ(1–42) have remained elusive. Here we present the atomic...

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Publicado en:Nat Struct Mol Biol
Autores principales: Xiao, Yiling, Ma, Buyong, McElheny, Dan, Parthasarathy, Sudhakar, Long, Fei, Hoshi, Minako, Nussinov, Ruth, Ishii, Yoshitaka
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476499/
https://ncbi.nlm.nih.gov/pubmed/25938662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2991
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