Anti-tumor activity of WK88-1, a novel geldanamycin derivative, in gefitinib-resistant non-small cell lung cancers with Met amplification

Although epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) have been introduced for the treatment of non-small cell lung cancer (NSCLC), the emergence of secondary T790M mutation in EGFR or amplification of the Met proto-oncogene restrain the clinical success of EGFR-TKIs. Sinc...

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Bibliographic Details
Published in:Cancer Sci
Main Authors: Jang, Won-Jun, Jung, Sung-Keun, Kang, Jong-Soon, Jeong, Joo-Won, Bae, Moon-Kyoung, Joo, Sang Hoon, Park, Gyu Hwan, Kundu, Joydeb K, Hong, Young-Soo, Jeong, Chul-Ho
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2014
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4462346/
https://ncbi.nlm.nih.gov/pubmed/25117641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12497
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