Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors

Despite gains in survival, outcomes for patients with metastatic or recurrent rhabdomyosarcoma (RMS) remain dismal. In a collaboration between the National Cancer Institute, Children's Oncology Group, and Broad Institute, we performed whole-genome, whole-exome and transcriptome sequencing to ch...

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Pubblicato in:Cancer Discov
Autori principali: Shern, Jack F., Chen, Li, Chmielecki, Juliann, Wei, Jun S., Patidar, Rajesh, Rosenberg, Mara, Ambrogio, Lauren, Auclair, Daniel, Wang, Jianjun, Song, Young K., Tolman, Catherine, Hurd, Laura, Liao, Hongling, Zhang, Shile, Bogen, Dominik, Brohl, Andrew S., Sindiri, Sivasish, Catchpoole, Daniel, Badgett, Thomas, Getz, Gad, Mora, Jaume, Anderson, James R., Skapek, Stephen X., Barr, Frederic G., Meyerson, Matthew, Hawkins, Douglas S., Khan, Javed
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4462130/
https://ncbi.nlm.nih.gov/pubmed/24436047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0639
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