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Distinct Methylation Profiles Characterize Fusion-Positive and Fusion-Negative Rhabdomyosarcoma

Rhabdomyosarcoma comprises two major subtypes, fusion-positive (PAX3-FOXO1 or PAX7-FOXO1) and fusion-negative. To investigate the significance of DNA methylation in these subtypes, we analyzed methylation profiles of 37 rhabdomyosarcoma tumors and 10 rhabdomyosarcoma cell lines as well as 8 normal t...

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Detalhes bibliográficos
Publicado no:Mod Pathol
Main Authors: Sun, Wenyue, Chatterjee, Bishwanath, Wang, Yonghong, Stevenson, Holly S., Edelman, Daniel C., Meltzer, Paul S., Barr, Frederic G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6345526/
https://ncbi.nlm.nih.gov/pubmed/26226845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/modpathol.2015.82
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