Transthyretin sequesters amyloid beta protein and prevents amyloid formation.

The cardinal pathological features of Alzheimer disease are depositions of aggregated amyloid beta protein (A beta) in the brain and cerebrovasculature. However, the A beta is found in a soluble form in cerebrospinal fluid in healthy individuals and patients with Alzheimer disease. We postulate that...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Schwarzman, A L, Gregori, L, Vitek, M P, Lyubski, S, Strittmatter, W J, Enghilde, J J, Bhasin, R, Silverman, J, Weisgraber, K H, Coyle, P K
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1994
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44607/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8078889/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.18.8368
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