Cytotoxic effects of replication-competent adenoviruses on human esophageal carcinoma are enhanced by forced p53 expression

BACKGROUND: Improvement of transduction and augmentation of cytotoxicity are crucial for adenoviruses (Ad)-mediated gene therapy for cancer. Down-regulated expression of type 5 Ad (Ad5) receptors on human tumors hampered Ad-mediated transduction. Furthermore, a role of the p53 pathways in cytotoxici...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Yang, Shan, Kawamura, Kiyoko, Okamoto, Shinya, Yamauchi, Suguru, Shingyoji, Masato, Sekine, Ikuo, Kobayashi, Hiroshi, Tada, Yuji, Tatsumi, Koichiro, Hiroshima, Kenzo, Shimada, Hideaki, Tagawa, Masatoshi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4460641/
https://ncbi.nlm.nih.gov/pubmed/26059686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1482-8
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