A clinical protocol to inhibit the HGF/c-Met pathway for malignant mesothelioma with an intrapleural injection of adenoviruses expressing the NK4 gene

BACKGROUND: The hepatocyte growth factor (HGF)/c-Met signal pathway is up-regulated in human mesothelioma and suppression of the HGF/c-Met signaling with a competitive inhibitor, NK4 homologous to HGF in the structure, produced anti-tumor effects to mesothelioma in a preclinical study. Mesothelioma...

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Detalhes bibliográficos
Publicado no:Springerplus
Main Authors: Tada, Yuji, Hiroshima, Kenzo, Shimada, Hideaki, Morishita, Naoya, Shirakawa, Toshiro, Matsumoto, Kunio, Shingyoji, Masato, Sekine, Ikuo, Tatsumi, Koichiro, Tagawa, Masatoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2015
Assuntos:
Study Protocol
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4503710/
https://ncbi.nlm.nih.gov/pubmed/26191485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40064-015-1123-3
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