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Erbin is a novel substrate of the Sag-βTrCP E3 ligase that regulates Kras(G12D)-induced skin tumorigenesis
SAG/RBX2 is the RING (really interesting new gene) component of Cullin-RING ligase, which is required for its activity. An organ-specific role of SAG in tumorigenesis is unknown. We recently showed that Sag/Rbx2, upon lung-targeted deletion, suppressed Kras(G12D)-induced tumorigenesis via inactivati...
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| Publicado no: | J Cell Biol |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4460146/ https://ncbi.nlm.nih.gov/pubmed/26056141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201411104 |
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