Spermatogenesis rescue in a mouse deficient for the ubiquitin ligase SCF(β-TrCP) by single substrate depletion

β-TrCP, the substrate recognition subunit of a Skp1–Cul1–F-box (SCF) ubiquitin ligase, is ubiquitously expressed from two distinct paralogs, targeting many regulatory proteins for proteasomal degradation. We generated inducible β-TrCP hypomorphic mice and found that they are surprisingly healthy, ye...

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Detalhes bibliográficos
Main Authors: Kanarek, Naama, Horwitz, Elad, Mayan, Inbal, Leshets, Michael, Cojocaru, Gady, Davis, Matti, Tsuberi, Ben-Zion, Pikarsky, Eli, Pagano, Michele, Ben-Neriah, Yinon
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2010
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2827842/
https://ncbi.nlm.nih.gov/pubmed/20194439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.551610
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