Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody

The respiratory syncytial virus (RSV) fusion (F) glycoprotein prefusion conformation is the target of most RSV-neutralizing activity in human sera, but its metastability has hindered characterization. To overcome this obstacle, we identified prefusion-specific antibodies which were substantially mor...

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Veröffentlicht in:Science
Hauptverfasser: McLellan, Jason S., Chen, Man, Leung, Sherman, Graepel, Kevin W., Du, Xiulian, Yang, Yongping, Zhou, Tongqing, Baxa, Ulrich, Yasuda, Etsuko, Beaumont, Tim, Kumar, Azad, Modjarrad, Kayvon, Zheng, Zizheng, Zhao, Min, Xia, Ningshao, Kwong, Peter D., Graham, Barney S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4459498/
https://ncbi.nlm.nih.gov/pubmed/23618766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1234914
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