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Rapid mitochondrial dysfunction mediates TNF-alpha-induced neurotoxicity

Tumor necrosis factor alpha (TNF-α) is known to exacerbate ischemic brain injury; however, the mechanism is unknown. Previous studies have evaluated the effects of TNF-α on neurons with long exposures to high doses of TNF-α, which is not pathophysiologically relevant. We characterized the rapid effe...

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Publicat a:J Neurochem
Autors principals: Doll, Danielle N., Rellick, Stephanie L., Barr, Taura L., Ren, Xuefang, Simpkins, James W.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4459129/
https://ncbi.nlm.nih.gov/pubmed/25492727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.13008
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