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A Phosphoproteomic Comparison of B-RAF(V600E) and MKK1/2 Inhibitors in Melanoma Cells

Inhibitors of oncogenic B-RAF(V600E) and MKK1/2 have yielded remarkable responses in B-RAF(V600E)-positive melanoma patients. However, the efficacy of these inhibitors is limited by the inevitable onset of resistance. Despite the fact that these inhibitors target the same pathway, combination treatm...

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Detalhes bibliográficos
Publicado no:Mol Cell Proteomics
Main Authors: Stuart, Scott A., Houel, Stephane, Lee, Thomas, Wang, Nan, Old, William M., Ahn, Natalie G.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458723/
https://ncbi.nlm.nih.gov/pubmed/25850435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M114.047233
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