Effects of impaired membrane interactions on α-synuclein aggregation and neurotoxicity

The post-mortem brains of individuals with Parkinson’s disease (PD) and other synucleinopathy disorders are characterized by the presence of aggregated forms of the presynaptic protein α-synuclein (aSyn). Understanding the molecular mechanism of aSyn aggregation is essential for the development of n...

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Bibliographic Details
Published in:Neurobiol Dis
Main Authors: Ysselstein, Daniel, Joshi, Mehul, Mishra, Vartika, Griggs, Amy M., Asiago, Josephat M., McCabe, George P., Stanciu, Lia A., Post, Carol Beth, Rochet, Jean-Christophe
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458405/
https://ncbi.nlm.nih.gov/pubmed/25931201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2015.04.007
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