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Glutaminase Activity Determines Cytotoxicity of L-Asparaginases on Most Leukemia Cell Lines
L-Asparaginase (ASNase) is a front-line chemotherapy for acute lymphoblastic leukemia (ALL), which acts by deaminating asparagine and glutamine. To evaluate the importance of glutaminase activity, we exploited a recently developed mutant of Helicobacter pylori ASNase (dm HpA), with amino acid substi...
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| Udgivet i: | Leuk Res |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4458142/ https://ncbi.nlm.nih.gov/pubmed/25941002 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2015.04.008 |
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