Glutaminase Activity Determines Cytotoxicity of L-Asparaginases on Most Leukemia Cell Lines

L-Asparaginase (ASNase) is a front-line chemotherapy for acute lymphoblastic leukemia (ALL), which acts by deaminating asparagine and glutamine. To evaluate the importance of glutaminase activity, we exploited a recently developed mutant of Helicobacter pylori ASNase (dm HpA), with amino acid substi...

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Bibliographic Details
Published in:Leuk Res
Main Authors: Parmentier, Jean Hugues, Maggi, Maristella, Tarasco, Erika, Scotti, Claudia, Avramis, Vassilios I, Mittelman, Steven D.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458142/
https://ncbi.nlm.nih.gov/pubmed/25941002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2015.04.008
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