A protease-resistant Escherichia coli asparaginase with outstanding stability and enhanced anti-leukaemic activity in vitro

L-Asparaginases (ASNases) have been used as first line drugs for paediatric Acute Lymphoblastic Leukaemia (ALL) treatment for more than 40 years. Both the Escherichia coli (EcAII) and Erwinia chrysanthemi (ErAII) type II ASNases currently used in the clinics are characterized by high in vivo instabi...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Maggi, Maristella, Mittelman, Steven D., Parmentier, Jean Hugues, Colombo, Giorgio, Meli, Massimiliano, Whitmire, Jeannette Marie, Merrell, D. Scott, Whitelegge, Julian, Scotti, Claudia
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2017
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5670125/
https://ncbi.nlm.nih.gov/pubmed/29101342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15075-4
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