A protease-resistant Escherichia coli asparaginase with outstanding stability and enhanced anti-leukaemic activity in vitro

L-Asparaginases (ASNases) have been used as first line drugs for paediatric Acute Lymphoblastic Leukaemia (ALL) treatment for more than 40 years. Both the Escherichia coli (EcAII) and Erwinia chrysanthemi (ErAII) type II ASNases currently used in the clinics are characterized by high in vivo instabi...

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Udgivet i:Sci Rep
Main Authors: Maggi, Maristella, Mittelman, Steven D., Parmentier, Jean Hugues, Colombo, Giorgio, Meli, Massimiliano, Whitmire, Jeannette Marie, Merrell, D. Scott, Whitelegge, Julian, Scotti, Claudia
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5670125/
https://ncbi.nlm.nih.gov/pubmed/29101342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15075-4
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