Febuxostat improves outcome in a rat model of cancer cachexia

BACKGROUND: Activity of xanthine oxidase is induced in cancer cachexia, and its inhibition by allopurinol or oxypurinol improves survival and reduces wasting in the Yoshida hepatoma cancer cachexia model. Here, we tested the effects of the second-generation xanthine oxidase inhibitor febuxostat comp...

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Detalhes bibliográficos
Publicado no:J Cachexia Sarcopenia Muscle
Main Authors: Konishi, Masaaki, Pelgrim, Loes, Tschirner, Anika, Baumgarten, Anna, von Haehling, Stephan, Palus, Sandra, Doehner, Wolfram, Anker, Stefan D, Springer, Jochen
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458083/
https://ncbi.nlm.nih.gov/pubmed/26136193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcsm.12017
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