Krt19(+)/Lgr5(−) cells are radioresistant cancer initiating stem cells in the colon and intestine

The colonic and intestinal epithelium are renewed every 3 days. In the intestine there are at least two principal stem cell pools. The first contains rapid cycling crypt based columnar (CBC) Lgr5(+) cells, while the second is comprised of slower cycling Bmi1-expressing cells at the +4 position above...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Asfaha, Samuel, Hayakawa, Yoku, Muley, Ashlesha, Stokes, Sarah, Graham, Trevor A., Ericksen, Russell, Westphalen, Christoph B., von Burstin, Johannes, Mastracci, Teresa L., Worthley, Daniel L., Guha, Chandhan, Quante, Michael, Rustgi, Anil K., Wang, Timothy C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457942/
https://ncbi.nlm.nih.gov/pubmed/26046762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2015.04.013
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