Long-lived intestinal tuft cells serve as colon cancer–initiating cells

Doublecortin-like kinase 1 protein (DCLK1) is a gastrointestinal tuft cell marker that has been proposed to identify quiescent and tumor growth–sustaining stem cells. DCLK1(+) tuft cells are increased in inflammation-induced carcinogenesis; however, the role of these cells within the gastrointestina...

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Hauptverfasser: Westphalen, C. Benedikt, Asfaha, Samuel, Hayakawa, Yoku, Takemoto, Yoshihiro, Lukin, Dana J., Nuber, Andreas H., Brandtner, Anna, Setlik, Wanda, Remotti, Helen, Muley, Ashlesha, Chen, Xiaowei, May, Randal, Houchen, Courtney W., Fox, James G., Gershon, Michael D., Quante, Michael, Wang, Timothy C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934168/
https://ncbi.nlm.nih.gov/pubmed/24487592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI73434
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