Long-lived intestinal tuft cells serve as colon cancer–initiating cells

Doublecortin-like kinase 1 protein (DCLK1) is a gastrointestinal tuft cell marker that has been proposed to identify quiescent and tumor growth–sustaining stem cells. DCLK1(+) tuft cells are increased in inflammation-induced carcinogenesis; however, the role of these cells within the gastrointestina...

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Bibliografische gegevens
Hoofdauteurs: Westphalen, C. Benedikt, Asfaha, Samuel, Hayakawa, Yoku, Takemoto, Yoshihiro, Lukin, Dana J., Nuber, Andreas H., Brandtner, Anna, Setlik, Wanda, Remotti, Helen, Muley, Ashlesha, Chen, Xiaowei, May, Randal, Houchen, Courtney W., Fox, James G., Gershon, Michael D., Quante, Michael, Wang, Timothy C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2014
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934168/
https://ncbi.nlm.nih.gov/pubmed/24487592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI73434
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