Distinct Levels of Radioresistance in Lgr5+ Colonic Epithelial Stem Cells versus Lgr5+ Small Intestinal Stem Cells

While small and large intestines possess seemingly similar Wnt-driven Leucine-rich repeat-containing G protein coupled receptor 5 (Lgr5)+ adult epithelial stem cells, we report here that the two organs exhibit distinct mechanisms of tissue response to ionizing radiation. Employing Lgr5-lacZ transgen...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Hua, Guoqiang, Wang, Chu, Pan, Yan, Zeng, Zhaoshi, Lee, Sang Gyu, Martin, Maria Laura, Haimovitz-Friedman, Adriana, Fuks, Zvi, Paty, Philip B., Kolesnick, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5621135/
https://ncbi.nlm.nih.gov/pubmed/28202528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-2870
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