The HSP90 inhibitor ganetespib potentiates the antitumor activity of EGFR tyrosine kinase inhibition in mutant and wild-type non-small cell lung cancer

Small molecule inhibitors of epidermal growth factor receptor (EGFR) tyrosine kinase activity, such as erlotinib and gefitinib, revolutionized therapy for non-small cell lung cancer (NSCLC) patients whose tumors harbor activating EGFR mutations. However, mechanisms to overcome the invariable develop...

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Detalhes bibliográficos
Publicado no:Target Oncol
Main Authors: Smith, Donald L., Acquaviva, Jaime, Sequeira, Manuel, Jimenez, John-Paul, Zhang, Chaohua, Sang, Jim, Bates, Richard C., Proia, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2014
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457934/
https://ncbi.nlm.nih.gov/pubmed/25077897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11523-014-0329-6
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