Effective Optimization of Antibody Affinity by Phage Display Integrated with High-Throughput DNA Synthesis and Sequencing Technologies

Phage display technology has been widely used for antibody affinity maturation for decades. The limited library sequence diversity together with excessive redundancy and labour-consuming procedure for candidate identification are two major obstacles to widespread adoption of this technology. We here...

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Vydáno v:PLoS One
Hlavní autoři: Hu, Dongmei, Hu, Siyi, Wan, Wen, Xu, Man, Du, Ruikai, Zhao, Wei, Gao, Xiaolian, Liu, Jing, Liu, Haiyan, Hong, Jiong
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457833/
https://ncbi.nlm.nih.gov/pubmed/26046845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129125
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