Clonal array profiling of scFv-displaying phages for high-throughput discovery of affinity-matured antibody mutants

"Antibody-breeding" approach potentially generates therapeutic/diagnostic antibody mutants with greater performance than native antibodies. Therein, antibody fragments (e.g., single-chain Fv fragments; scFvs) with a variety of mutations are displayed on bacteriophage to generate diverse ph...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Kiguchi, Yuki, Oyama, Hiroyuki, Morita, Izumi, Morikawa, Mai, Nakano, Asuka, Fujihara, Wakana, Inoue, Yukari, Sasaki, Megumi, Saijo, Yuki, Kanemoto, Yuki, Murayama, Kaho, Baba, Yuki, Takeuchi, Atsuko, Kobayashi, Norihiro
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7445280/
https://ncbi.nlm.nih.gov/pubmed/32839506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-71037-3
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