Application of phage display to high throughput antibody generation and characterization

We have created a high quality phage display library containing over 10(10 )human antibodies and describe its use in the generation of antibodies on an unprecedented scale. We have selected, screened and sequenced over 38,000 recombinant antibodies to 292 antigens, yielding over 7,200 unique clones....

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Autori principali: Schofield, Darren J, Pope, Anthony R, Clementel, Veronica, Buckell, Jenny, Chapple, Susan DJ, Clarke, Kay F, Conquer, Jennie S, Crofts, Anna M, Crowther, Sandra RE, Dyson, Michael R, Flack, Gillian, Griffin, Gareth J, Hooks, Yvette, Howat, William J, Kolb-Kokocinski, Anja, Kunze, Susan, Martin, Cecile D, Maslen, Gareth L, Mitchell, Joanne N, O'Sullivan, Maureen, Perera, Rajika L, Roake, Wendy, Shadbolt, S Paul, Vincent, Karen J, Warford, Anthony, Wilson, Wendy E, Xie, Jane, Young, Joyce L, McCafferty, John
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2007
Soggetti:
Method
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258204/
https://ncbi.nlm.nih.gov/pubmed/18047641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2007-8-11-r254
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