Targeting Cdc20 as a novel cancer therapeutic strategy

The Anaphase Promoting Complex (APC, also called APC/C) regulates cell cycle progression by forming two closely related, but functionally distinct E3 ubiquitin ligase sub-complexes, APC(Cdc20) and APC(Cdh1), respectively. Emerging evidence has begun to reveal that Cdc20 and Cdh1 have opposing functi...

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Bibliografiske detaljer
Udgivet i:Pharmacol Ther
Main Authors: Wang, Lixia, Zhang, Jinfang, Wan, Lixin, Zhou, Xiuxia, Wang, Zhiwei, Wei, Wenyi
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457591/
https://ncbi.nlm.nih.gov/pubmed/25850036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharmthera.2015.04.002
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