Endogenous murine Aβ increases amyloid deposition in APP23 but not in APPPS1 transgenic mice

Endogenous murine amyloid-β peptide (Aβ) is expressed in most Aβ precursor protein (APP) transgenic mouse models of Alzheimer's disease but its contribution to β-amyloidosis remains unclear. We demonstrate ~35% increased cerebral Aβ load in APP23 transgenic mice compared to age-matched APP23 mi...

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Detalhes bibliográficos
Publicado no:Neurobiol Aging
Main Authors: Mahler, Jasmin, Morales-Corraliza, Jose, Stolz, Julia, Skodras, Angelos, Radde, Rebecca, Duma, Carmen C., Eisele, Yvonne S., Mazzella, Matthew J., Wong, Harrison, Klunk, William E., Nilsson, K. Peter R., Staufenbiel, Matthias, Mathews, Paul M., Jucker, Mathias, Wegenast-Braun, Bettina M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457564/
https://ncbi.nlm.nih.gov/pubmed/25911278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2015.03.011
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