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Identification of Novel Small Molecule Inhibitors of Oncogenic RET Kinase
Oncogenic mutation of the RET receptor tyrosine kinase is observed in several human malignancies. Here, we describe three novel type II RET tyrosine kinase inhibitors (TKI), ALW-II-41-27, XMD15-44 and HG-6-63-01, that inhibit the cellular activity of oncogenic RET mutants at two digit nanomolar conc...
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| Udgivet i: | PLoS One |
|---|---|
| Main Authors: | , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4457528/ https://ncbi.nlm.nih.gov/pubmed/26046350 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0128364 |
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