Drug screening strategy for human membrane proteins: from NMR protein backbone structure to in silica- and NMR-screened hits

About 8,000 genes encode membrane proteins in the human genome. The information about their druggability will be very useful to facilitate drug discovery and development. The main problem, however, consists of limited structural and functional information about these proteins because they are diffic...

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Vydáno v:Biochem Biophys Res Commun
Hlavní autoři: Lindert, Steffen, Maslennikov, Innokentiy, Chiu, Ellis, Pierce, Levi C, McCammon, J. Andrew, Choe, Senyon
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457379/
https://ncbi.nlm.nih.gov/pubmed/24525125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2014.01.179
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