Visualizing translocation dynamics and nascent transcript errors in paused RNA polymerases in vivo

BACKGROUND: Transcription elongation is frequently interrupted by pausing signals in DNA, with downstream effects on gene expression. Transcription errors also induce prolonged pausing, which can lead to a destabilized genome by interfering with DNA replication. Mechanisms of pausing associated with...

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Vydáno v:Genome Biol
Hlavní autoři: Imashimizu, Masahiko, Takahashi, Hiroki, Oshima, Taku, McIntosh, Carl, Bubunenko, Mikhail, Court, Donald L., Kashlev, Mikhail
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457086/
https://ncbi.nlm.nih.gov/pubmed/25976475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0666-5
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