Intrinsic Translocation Barrier as an Initial Step in Pausing by RNA Polymerase II

Pausing of RNA polymerase II (RNAP II) by backtracking on the DNA is a major regulatory mechanism in control of eukaryotic transcription. Backtracking occurs by extrusion of the 3’ end of the RNA from the active center after bond formation and before translocation of RNAP II on DNA. In several docum...

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Udgivet i:J Mol Biol
Main Authors: Imashimizu, Masahiko, Kireeva, Maria L., Lubkowska, Lucyna, Gotte, Deanna, Parks, Adam R., Strathern, Jeffrey N., Kashlev, Mikhail
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7649676/
https://ncbi.nlm.nih.gov/pubmed/23238253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.12.002
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