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Heterogeneous disease progression and treatment response in a C3HeB/FeJ mouse model of tuberculosis

Mice are the most commonly used species for non-clinical evaluations of drug efficacy against tuberculosis (TB). Unlike commonly used strains, C3HeB/FeJ mice develop caseous necrosis in the lung, which might alter the representation of drug efficacy in a way that is more like human TB. Because the d...

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發表在:Dis Model Mech
Main Authors: Lanoix, Jean-Philippe, Lenaerts, Anne J., Nuermberger, Eric L.
格式: Artigo
語言:Inglês
出版: The Company of Biologists 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457036/
https://ncbi.nlm.nih.gov/pubmed/26035868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.019513
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