Membrane proximal ectodomain cleavage of MUC16 occurs in the acidifying Golgi/post-Golgi compartments

MUC16, precursor of the most widely used ovarian cancer biomarker CA125, is up regulated in multiple malignancies and is associated with poor prognosis. While the pro-tumorigenic and metastatic roles of MUC16 are ascribed to the cell-associated carboxyl-terminal MUC16 (MUC16-Cter), the exact biochem...

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Publicat a:Sci Rep
Autors principals: Das, Srustidhar, Majhi, Prabin D., Al-Mugotir, Mona H., Rachagani, Satyanarayana, Sorgen, Paul, Batra, Surinder K.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456727/
https://ncbi.nlm.nih.gov/pubmed/26044153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09759
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