MUC16 regulates TSPYL5 for lung cancer cell growth and chemoresistance by suppressing p53

PURPOSE: MUC16, a tumor biomarker and cell surface associated mucin, is overexpressed in various cancers; however, its role in lung cancer pathogenesis is unknown. Here, we have explored the mechanistic role of MUC16 in lung cancer. EXPERIMENTAL DESIGN: To identify the functional role of MUC16, stab...

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Dettagli Bibliografici
Pubblicato in:Clin Cancer Res
Autori principali: Lakshmanan, Imayavaramban, Salfity, Shereen, Seshacharyulu, Parthasarathy, Rachagani, Satyanarayana, Thomas, Abigail, Das, Srustidhar, Majhi, Prabin D., Nimmakayala, Rama Krishna, Vengoji, Raghupathy, Lele, Subodh M., Ponnusamy, Moorthy P., Batra, Surinder K., Ganti, Apar Kishor
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5511558/
https://ncbi.nlm.nih.gov/pubmed/28196872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-2530
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