Carboxyl-terminal domain of MUC16 imparts tumorigenic and metastatic functions through nuclear translocation of JAK2 to pancreatic cancer cells

MUC16 (CA125) is a type-I transmembrane glycoprotein that is up-regulated in multiple cancers including pancreatic cancer (PC). However, the existence and role of carboxyl-terminal MUC16 generated following its cleavage in PC is unknown. Our previous study using a systematic dual-epitope tagged doma...

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Udgivet i:Oncotarget
Main Authors: Das, Srustidhar, Rachagani, Satyanarayana, Torres-Gonzalez, Maria P., Lakshmanan, Imayavaramban, Majhi, Prabin D., Smith, Lynette M., Wagner, Kay-Uwe, Batra, Surinder K.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467401/
https://ncbi.nlm.nih.gov/pubmed/25691062
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