Structure of the Vif-binding domain of the antiviral enzyme APOBEC3G

The human APOBEC3G (A3G) DNA cytosine deaminase restricts and hypermutates DNA-based parasites including HIV-1. The viral infectivity factor (Vif) prevents restriction by triggering A3G degradation. While the structure of the A3G catalytic domain is known, the structure of the N-terminal Vif-binding...

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Bibliografiska uppgifter
I publikationen:Nat Struct Mol Biol
Huvudupphovsmän: Kouno, Takahide, Luengas, Elizabeth M., Shigematsu, Megumi, Shandilya, Shivender M.D., Zhang, JingYing, Chen, Luan, Hara, Mayuko, Schiffer, Celia A., Harris, Reuben S., Matsuo, Hiroshi
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456288/
https://ncbi.nlm.nih.gov/pubmed/25984970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3033
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