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Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C-terminus
The molecular circadian clock in mammals is generated from transcriptional activation by the bHLH-PAS transcription factor CLOCK–BMAL1 and subsequent repression by PERIOD and CRYPTOCHROME (CRY). The mechanism by which CRYs repress CLOCK–BMAL1 to close the negative feedback loop and generate 24-hour...
Tallennettuna:
| Julkaisussa: | Nat Struct Mol Biol |
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| Päätekijät: | , , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2015
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4456216/ https://ncbi.nlm.nih.gov/pubmed/25961797 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3018 |
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