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Mechanisms of HIV-1 Tat Neurotoxicity via CDK5 Translocation and Hyper-Activation: Role in HIV-Associated Neurocognitive Disorders

The advent of more effective antiretroviral therapies has reduced the frequency of HIV dementia, however the prevalence of milder HIV associated neurocognitive disorders [HAND] is actually rising. Neurodegenerative mechanisms in HAND might include toxicity by secreted HIV-1 proteins such as Tat, gp1...

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Bibliografische gegevens
Gepubliceerd in:Curr HIV Res
Hoofdauteurs: Fields, Jerel Adam, Dumaop, Wilmar, Crews, Leslie, Adame, Anthony, Spencer, Brian, Metcalf, Jeff, He, Johnny, Rockenstein, Edward, Masliah, Eliezer
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4455959/
https://ncbi.nlm.nih.gov/pubmed/25760044
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