Mechanisms of HIV-1 Tat Neurotoxicity via CDK5 Translocation and Hyper-Activation: Role in HIV-Associated Neurocognitive Disorders

The advent of more effective antiretroviral therapies has reduced the frequency of HIV dementia, however the prevalence of milder HIV associated neurocognitive disorders [HAND] is actually rising. Neurodegenerative mechanisms in HAND might include toxicity by secreted HIV-1 proteins such as Tat, gp1...

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Bibliographic Details
Published in:Curr HIV Res
Main Authors: Fields, Jerel Adam, Dumaop, Wilmar, Crews, Leslie, Adame, Anthony, Spencer, Brian, Metcalf, Jeff, He, Johnny, Rockenstein, Edward, Masliah, Eliezer
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4455959/
https://ncbi.nlm.nih.gov/pubmed/25760044
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