SDF-1α stiffens myeloma bone marrow mesenchymal stromal cells through the activation of RhoA-ROCK-Myosin II

Multiple myeloma (MM) is a B lymphocyte malignancy that remains incurable despite extensive research efforts. This is due, in part, to frequent disease recurrences associated with the persistence of myeloma cancer stem cells (mCSCs). Bone marrow mesenchymal stromal cells (BMSCs) play critical roles...

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Vydáno v:Int J Cancer
Hlavní autoři: Choi, Dong Soon, Stark, Daniel J., Raphael, Robert M., Wen, Jianguo, Su, Jing, Zhou, Xiaobo, Chang, Chung-Che, Zu, Youli
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4454501/
https://ncbi.nlm.nih.gov/pubmed/25137150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.29145
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